Comedy & Music

Uptown 21 is known for housing Jacksonville's most ambitious promoters. Their uncanny abilities to attract chart-topping celebrities, musicians, comics and artists to our venue allow patrons to enjoy major metropolitan-style nightlife entertainment right here in in beautiful Jacksonville, FL. Weekly, our resident DJ's and house band, give a twist of R&B and Hip-Hip to entice our ridiculously gorgeous and mature audiences onto the dance floor.

Uptown 21 is designed to tempt all of the senses. The space is clean, understated, and chic. It holds a large rasied and floor stage, vast open bar, full kitchen and plush intimate seating. Located just off I-95 and University Blvd, Uptown 21 is perfect for your next event. (i.e., wedding receptions, concerts, private parties, large parties.) Either way, we'd love to have you. For more information about our venue and opportunities please contact us.